Obesity is chronic. Most patients continue. Here's what years 2+ look like.
About this article
Reviewed byDr. J. Bottoni, M.D.
RoleEditor-in-Chief, Medicine
First publishedMay 20, 2026
Last reviewedMay 20, 2026
Page typeIn-depth editorial guide
Sources15+ cited sources
Continued weight loss vs maintenance
Trial follow-up data suggest most weight loss occurs in year 1; year 2 may see additional modest loss or stable maintenance.
Dose considerations
Many patients stabilize at sub-maximum dose producing target effect with acceptable side effects. Going to max just because available is not required.
Side effect evolution
GI symptoms typically resolved by year 2. Patients describe therapy as 'easy' relative to initiation.
Lifestyle integration
Eating patterns are typically settled. Exercise routines established. Many patients describe quality of life as substantially improved.
Discontinuation choice
If considering discontinuation: plan timing carefully. Regain is the default. Lifestyle change can mitigate but not eliminate.