Six months is enough time for most patients to reach maintenance dose and see substantial body composition change.
About this article
Reviewed byDr. J. Bottoni, M.D.
RoleEditor-in-Chief, Medicine
First publishedMay 20, 2026
Last reviewedMay 20, 2026
Page typeIn-depth editorial guide
Sources15+ cited sources
Where most patients are at 6 months
Dose: 1.7–2.4 mg sema or 10–15 mg tirz typical. Weight loss: 12–18% of starting body weight is typical. Many at 80% of their final response.
Body composition
Without resistance training: ~70% fat / 30% lean mass loss. With resistance training + protein 1.6–2.0 g/kg: shifts toward 80%+ fat loss.
Cardiometabolic markers
BP down 3–5 mmHg typical. LDL down 5–10%. Triglycerides down 15–30%. A1c down 1–2% in T2D. Sleep often improved.
Lifestyle integration
Eating patterns largely settled. Most patients describe 'food noise quieting.' Exercise tolerance improved with weight loss.