Your first 90 days — the titration period

Days 0–90: ascending through dose tiers. Major patterns and milestones.

Days 0–28: 0.25 mg sema / 2.5 mg tirz

Initiation tier. Tolerance development. Modest weight loss (2–6 lb typical).

Days 28–56: 0.5 mg sema / 5 mg tirz

First effective dose for many patients. Appetite reduction more pronounced. Weight loss accelerates (additional 4–8 lb typical).

Days 56–84: 1.0 mg sema / 7.5 mg tirz

Approaching maintenance for many. Weight loss continuing (additional 4–8 lb typical).

Days 84–90: review

Lab follow-up at 90 days. Assess tolerance, response, and plan further titration or hold at current dose.

Total 90-day weight loss

Typical: 10–22 lb (5–10% of starting weight). Trial data shows ongoing weight loss through 68–72 weeks at maintenance dose.