Refrigeration requirements, what to do if cold chain is broken, travel considerations.
About this article
Reviewed byDr. Samuel Lora, M.D.
RolePharmacology & Compounding Reviewer
First publishedMay 20, 2026
Last reviewedMay 20, 2026
Page typeIn-depth editorial guide
Sources15+ cited sources
Standard storage
- Temperature: 36–46°F (2–8°C)
- Light: Protect from light (keep in original container)
- Position: Refrigerator shelf (not door)
- Do not freeze: Freezing destroys the peptide structure
Receiving a shipment
- Open immediately on arrival.
- Verify ice packs are still cold/partially frozen.
- Inspect vial: clear, colorless to slightly yellow.
- Refrigerate within 30 minutes of receipt.
Cold chain failure signs
Do NOT use if:
- Ice packs fully melted and warm to touch
- Vial at room temperature when handled
- Temperature indicator (if included) shows out-of-range
- Cloudy or discolored solution
- Visible precipitate
Contact your provider immediately; reputable providers will replace.
Travel
Short trips (under 24 hours): Insulated cooler with ice packs. Keep at 36–46°F.
Air travel: Carry-on in insulated bag. Most pen-injectors and vials are TSA-compatible. Bring prescription paperwork. Letter from provider helpful for international travel.
Out-of-temperature periods: Most GLP-1 preparations tolerate up to a few hours at room temperature without losing potency. Days at room temperature: discard.
Beyond-use dates
Each vial has a beyond-use date determined by the compounding pharmacy. Typically 28–60 days from preparation under refrigeration. Use within this window.