GLP-1 therapy works better paired with structured lifestyle change. STEP and SURMOUNT trials included lifestyle as part of protocol.
Protein
1.6–2.0 g/kg target body weight (not current). Critical for muscle preservation. See nutrition.
Resistance training
2–3 sessions/wk. Major muscle groups. Progressive overload. Critical for muscle preservation. See exercise.
Aerobic activity
150 min/wk moderate or 75 min/wk vigorous. Standard guidelines apply.
Sleep
7–9 hours. Sleep restriction undermines weight loss and increases hunger hormones.
Hydration
Especially important on GLP-1 (GI symptoms + reduced thirst). 64+ oz daily baseline.
Stress / emotional regulation
GLP-1 reduces food noise but doesn't eliminate emotional eating triggers. Behavioral support where relevant.